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Many happen to be valuable mainly because they bind selectively to possibly the CB1 or CB2 receptors, whereas THC has an identical affinity for both equally. Tritium-labelled cannabinoids for example CP-fifty five,940 were being instrumental in identifying the cannabinoid receptors from the early nineties.[53]
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Most artificial cannabinoids are agonists from the cannabinoid receptors. They are already meant to be comparable to THC,[9] the organic cannabinoid with the strongest binding affinity to your CB1 receptor, which happens to be associated with the psychoactive effects or "high" of marijuana.[ten] These artificial analogs often have better binding affinity and better potency towards the CB1 receptors.
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